Clinical Significance of National Institutes of Health Classification in Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Sung Yun-Hsien, 정재흥, Ryang Seung-Hoon, 김성진, 김광진,
소속 상세정보
( Sung Yun-Hsien )
Yonsei University Wonju College of Medicine Department of Urology
정재흥 ( Jung Jae-Hung )
Yonsei University Wonju College of Medicine Department of Urology
( Ryang Seung-Hoon )
Yonsei University Wonju College of Medicine Department of Urology
김성진 ( Kim Sung-Jin )
Yonsei University Wonju College of Medicine Department of Urology
김광진 ( Kim Kwang-Jin )
Yonsei University Wonju College of Medicine Department of Urology
KMID : 0358320140550040276
Abstract
Purpose: We determined the effects of alpha-blockers and quinolone in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) classified by National Institute of Health (NIH) consensus group.
Materials and Methods: Data from a total of 111 patients who were diagnosed with CP/CPPS between June 2010 and June 2012 were analyzed retrospectively. The patients were classified into group 1 (category IIIA, n=40) and group 2 (category IIIB, n=71). Treatment using alfuzosin and levofloxacin was given to both groups for 6 weeks. International Prostate Symptom Score (IPSS) and NIH Chronic Prostatitis Symptom Index were measured before and after therapy.
Results: Group 1 had a significant decrease in total IPSS score, CPSI pain score, CPSI quality of life (QoL) score, and total CPSI score (p=0.043, p=0.006, p=0.015, and p=0.006, respectively). Group 2 had a significant decrease in IPSS voiding symptom score, IPSS storage symptom score, total IPSS, CPSI pain score, CPSI voiding score, CPSI QoL score, and total CPSI score (p=0.002, p=0.004, p=0.001, p=0.001, p=0.006, p=0.001, and p=0.001, respectively). The CPSI score was reduced by 6 points or more in 50.0% of patients (n=18) in group 1 and in 51.6% of patients (n=32) in group 2. However, there was no statistically significant difference between the changes in IPSS and CPSI scores across the 2 groups.
Conclusions: Although combination treatment reduced the CPSI score in both groups, there was no significant difference between the groups after combination treatment. We suggest that factors other than inflammation also contribute to symptoms associated with CP/CPPS.
키워드
Adrenergic alpha-antagonist; Anti-bacterial agents; Leukocytes; Prostatitis
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