Unexpected Multidrug Resistance of Methicillin-Resistant Staphylococcus aureus in Urine Samples: A Single-Center Study
Lunacek Andreas, Koenig Uwe, Mrstik Christof, Radmayr Christian, Horninger Wolfgang, Plas Eugen,
소속 상세정보
( Lunacek Andreas )
Vienna Hanusch Krankenhaus Departments of Urology
( Koenig Uwe )
Vienna Hanusch Krankenhaus Departments of Pathology
( Mrstik Christof )
Vienna Hanusch Krankenhaus Departments of Urology
( Radmayr Christian )
Austria Medical University Innsbruck Department of Urology
( Horninger Wolfgang )
Austria Medical University Innsbruck Department of Urology
( Plas Eugen )
Vienna Hanusch Krankenhaus Departments of Urology
KMID : 0358320140550050349
Abstract
Purpose: Infections of methicillin-resistant Staphylococcus aureus (MRSA) are becoming an increasingly concerning clinical problem. The aim of this study was to assess the development of MRSA in urine cultures in a major public university-affiliated hospital and the therapeutical and hygiene-related possibilities for reducing resistance.
Materials and Methods: This study included 243 samples from patients diagnosed with MRSA infection over a period of 6 years. An agar diffusion test measured the effects of antimicrobial agents against bacteria grown in culture. The analyses were based on the guidelines of the Clinical and Laboratory Standards Institute.
Results: A regression analysis was performed, which showed 100% resistance to the following antibiotics throughout the entire testing period: carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin. However, a significant decrease in resistance was found for amikacin, gentamicin, clindamycin, levofloxacin, erythromycin, and mupirocin.
Conclusions: MRSA showed a decreasing trend of antimicrobial resistance, except against carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin, for which complete resistance was observed.
키워드
Methicillin-resistant Staphylococcus aureus; Multidrug resistance; Urine
원문 및 링크아웃 정보
등재저널 정보