Stereological Comparison of the Effects of Pentoxifylline, Captopril, Simvastatin, and Tamoxifen on Kidney and Bladder Structure After Partial Urethral Obstruction in Rats
Shirazi Mehdi, Soltani Mohammad-Reza, Jahanabadi Zahra, Abdollahifar Mohammad-Amin, Tanideh Nader,
소속 상세정보
( Shirazi Mehdi )
Shiraz University of Medical Sciences Histomorphometry and Stereology Research Centre
( Soltani Mohammad-Reza )
Shiraz University of Medical Sciences Faghihi Hospital Department of Urology
( Jahanabadi Zahra )
Shiraz University of Medical Sciences Faghihi Hospital Department of Urology
( Abdollahifar Mohammad-Amin )
Shiraz University of Medical Sciences Histomorphometry and Stereology Research Center
( Tanideh Nader )
Shiraz University of Medical Sciences Stem Cell and Transgenic Technology Research Center
KMID : 0358320140550110756
Abstract
Purpose: Limited studies have shown antifibrotic effects of pentoxifylline, captopril, simvastatin, and tamoxifen. No comparisons are available of the effects of these drugs on prevention of renal and bladder changes in partial urethral obstruction (PUO).
Materials and Methods: The rats were divided into six groups (n=7). The sham-operated rats (group I) only underwent laparotomy and did not receive any treatments. The PUO groups (group II-VI) received normal saline (PUO+NS), pentoxifylline (100 mg/kg/d; PUO+PEN), captopril (35 mg/kg/d; PUO+CAP), simvastatin (15 mg/kg/d; PUO+SIM), or tamoxifen (10 mg/kg/d; PUO+TAM) by gavage for 28 days. Then, the volume and/or length of the kidney components (tubules, vessels, and fibrous tissue) and the bladder components (epithelial and muscular layers, fibrous tissue, fibroblast and fibrocyte number) were quantitatively evaluated on the microscopic sections by use of stereological techniques.
Results: The volume of renal and bladder fibrosis was significantly ameliorated in the PUO+PEN group, followed by the PUO+CAP, PUO+SIM, and PUO+TAM groups. Also, the volume and length of the renal tubules and vessels and bladder layers were more significantly protected in the PUO+PEN group, followed by the PUO+CAP, PUO+SIM, and PUO+TAM groups.
Conclusions: Treatment of PUO with PEN was more effective in the prevention of renal and bladder fibrosis and in the preservation of renal and bladder structures.
키워드
Captopril; Pentoxifylline; Simvastatin; Tamoxifen; Urethral obstruction
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