Location of Positive Surgical Margin and Its Association With Biochemical Recurrence Rate Do Not Differ Significantly in Four Different Types of Radical Prostatectomy
Suh Yoon-Seok, Jang Hyeon-Jun, 송완, 이혜원, 김혜승, 전하림, 정병창, 서성일, 전성수, 최한용, 이현무,
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( Suh Yoon-Seok )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
( Jang Hyeon-Jun )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
송완 ( Song Wan )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
이혜원 ( Lee Hye-Won )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
김혜승 ( Kim Hye-Seung )
Sungkyunkwan University School of Medicine Samsung Medical Center Biostatistics and Clinical Epidemiology Center
전하림 ( Jeon Ha-Lim )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
정병창 ( Jeong Byong-Chang )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
서성일 ( Seo Seong-Il )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
전성수 ( Jeon Seong-Soo )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
최한용 ( Choi Han-Yong )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
이현무 ( Lee Hyun-Moo )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
KMID : 0358320140550120802
Abstract
Purpose: To analyze the location of the positive surgical margin (PSM) and its association with the biochemical recurrence (BCR) rate in cases of radical prostatectomy (RP) according to the type of surgery.
Materials and Methods: We retrospectively analyzed 1,880 cases of RP. Baseline characteristics were analyzed. Locations of the PSM were recorded in the four surgery groups as apex, anterior, posterolateral, and base and were analyzed by using chi-square test. The association of the location of the PSM with the BCR rate was analyzed by using Kaplan-Meier survival analysis according to the type of surgery, which included radical perineal prostatectomy (RPP, n=633), radical retroperitoneal prostatectomy (RRP, n=309), laparoscopic radical prostatectomy (LRP, n=164), and robot-assisted laparoscopic radical prostatectomy (RALRP, n=774).
Results: A PSM was found in a total of 336 cases (18%): 122 cases of RPP (18%), 67 cases of RRP (17%), 29 cases of LRP (17%), and 119 cases of RALRP (15%). The PSM rate did not differ significantly by surgical type (p=0.142). The location of the PSM was the apex in 136 cases (7.2%), anterior in 67 cases (3.5%), posterolateral in 139 cases (7.3%), and base in 95 cases (5.0%), and showed no significant difference according to surgical type (p=0.536, p=0.557, p=0.062, and p=0.109, respectively). The BCR rate according to the location of the PSM did not differ significantly for the four types of surgery (p=0.694, p=0.301, p=0.445, and p=0.309 for RPP, RRP, LRP, and RALRP, respectively).
Conclusions: The location of the PSM seemed to be unrelated to type of RP. There was no significant correlation between the BCR rate and the location of the PSM for any of the RP types.
키워드
Operative surgical procedures; Prostate; Prostate neoplasms; Prostatectomy; Recurrence
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