Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
이동현, 이천우, 권택민, 유달산, 정인갑, 홍준혁, 안한중, 김청수,
소속 상세정보
이동현 ( Lee Dong-Hyun )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
이천우 ( Lee Chun-Woo )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
권택민 ( Kwon Taek-Min )
University of Ulsan College of Medicine Ulsan University Hospital Department of Urology
유달산 ( You Dal-San )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
정인갑 ( Jeong In-Gab )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
홍준혁 ( Hong Jun-Hyuk )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
안한중 ( Ahn Han-Jong )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
김청수 ( Kim Choung-Soo )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
KMID : 0358320150560080565
Abstract
Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN).
Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR.
Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR.
Conclusions: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
키워드
Prostatectomy ; Prostatic intraepithelial neoplasia ; Prostatic neoplasms
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