Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy
Ali Liaqat, Shahzad Muhammad, Orakzai Nasir, Khan Ihsanullah, Ahmad Mubashira,
소속 상세정보
( Ali Liaqat )
Institute of Kidney Diseases Hayatabad Medical Complex Department of Urology
( Shahzad Muhammad )
Institute of Kidney Diseases Hayatabad Medical Complex Department of Urology
( Orakzai Nasir )
Institute of Kidney Diseases Hayatabad Medical Complex Department of Urology
( Khan Ihsanullah )
Institute of Kidney Diseases Hayatabad Medical Complex Department of Urology
( Ahmad Mubashira )
Khyber Teaching Hospital Department of Surgery
KMID : 0358320150560090650
Abstract
Purpose: To determine the efficacy of mitomycin C in reducing the recurrence of anterior urethral stricture after internal optical urethrotomy (IOU).
Materials and Methods: This was a randomized controlled trial conducted in the Department of Urology at the Institute of Kidney Diseases Peshawar from March 2011 to December 2013. A total of 151 patients who completed the study were divided into two groups by the lottery method. Group A (cases) comprised 78 patients in whom mitomycin C 0.1% was injected submucosally in the stricture after conventional IOU. Group B (controls) comprised 73 patients in whom IOU only was performed. Self-clean intermittent catheterization was not offered in either group. All patients were regularly followed up for 18 months. Recurrence was diagnosed by use of retrograde urethrogram in all patients and flexible urethroscopy in selected cases. Data were collected on a structured pro forma sheet and were analyzed by SPSS.
Results: The mean age of the patients in group A was 37.31±10.1 years and that in group B was 40.1±11.4 years. Recurrence of urethral stricture was recorded in 11 patients (14.1%) in group A and in 27 patients (36.9%) in group B (p=0.002). The mitomycin group also showed a delay in recurrence compared with the control group (p=0.002).
Conclusions: Recurrence of urethral stricture is high after optical urethrotomy. Mitomycin C was found to be highly effective in preventing the recurrence of urethral stricture after IOU.
키워드
Surgery; Urethral diseases; Urethral stricture; Urinary bladder neck obstruction
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