Dual Therapy Trial Using Esomeprazole and Amoxicillin as Third-line Rescue Therapy for Helicobacter pylori Infection
박현경, 이동호, 서승철, 서평주, 김나영, 정숙향, 김진욱, 황진혁, 박영수, 이상협, 신철민,
소속 상세정보
박현경 ( Park Hyun-Kyung )
서울대학교 의과대학 분당서울대학교병원 내과
이동호 ( Lee Dong-Ho )
서울대학교 의과대학 분당서울대학교병원 내과
서승철 ( Suh Seung-Chul )
서울대학교 의과대학 분당서울대학교병원 내과
서평주 ( Seo Pyoung-Ju )
서울대학교 의과대학 분당서울대학교병원 내과
김나영 ( Kim Na-Young )
서울대학교 의과대학 분당서울대학교병원 내과
정숙향 ( Jeong Sook-Hyang )
서울대학교 의과대학 분당서울대학교병원 내과
김진욱 ( Kim Jin-Wook )
서울대학교 의과대학 분당서울대학교병원 내과
황진혁 ( Hwang Jin-Hyeok )
서울대학교 의과대학 분당서울대학교병원 내과
박영수 ( Park Young-Soo )
서울대학교 의과대학 분당서울대학교병원 내과
이상협 ( Lee Sang-Hyub )
서울대학교 의과대학 분당서울대학교병원 내과
신철민 ( Shin Cheol-Min )
서울대학교 의과대학 분당서울대학교병원 내과
KMID : 0359020110440010033
Abstract
Background/Aims: The purpose of this study was to evaluate the efficacy and tolerability of dual therapy consisting of esomeprazole and amoxicillin as a rescue therapy for Helicobacter pylori infection.
Methods: From December 2009 to August 2010, 21 patients who experienced two consecutive eradication failures were included. They received esomeprazole (40 mg, b.i.d.) and amoxicillin (1,000 mg, b.i.d.) for 14 days as a third eradication regimen. Compliance and side effects were determined from an interview. H. pylori status was evaluated using the 13C urea breath test at least 6 weeks after treatment.
Results: The mean age of the patients was 59 years and included 52% males. Indications for treatment were functional dyspepsia (61.9%), peptic ulcer disease (28.6%), and gastric adenoma (9.5%). H. pylori was eradicated in 14 of 21 (66.7%) patients. Minor side effects were reported in three of the 21 patients (14.3%). These side effects consisted mainly of nausea and epigastric discomfort.
Conclusions: A 2-week course of dual therapy failed to show satisfactory results in third-line H. pylori eradication, but it was very safe and tolerable. Therefore, dual therapy constitutes an encouraging empirical strategy for the elderly and infirm patients with multiple previous eradication failures.
키워드
Helicobacter pylori; Therapy; Proton pump inhibitor; Amoxicillin
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