Low Grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Clinicopathological Factors Associated with Helicobacter pylori Eradication and Tumor Regression
최윤진, 이동호, 김지연, 권지은, 김재연, 조현진, 신철민, 김현영, 박영수, 김나영, 정현채, 송인성,
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최윤진 ( Choi Yoon-Jin )
서울대학교 의과대학 내과학교실
이동호 ( Lee Dong-Ho )
서울대학교 의과대학 분당서울대학교병원 내과
김지연 ( Kim Ji-Yeon )
서울대학교 의과대학 내과학교실
권지은 ( Kwon Ji-Eun )
서울대학교 의과대학 내과학교실
김재연 ( Kim Jae-Yeon )
서울대학교 의과대학 내과학교실
조현진 ( Jo Hyun-Jin )
서울대학교 의과대학 분당서울대학교병원 내과
신철민 ( Shin Cheol-Min )
서울대학교 의과대학 분당서울대학교병원 내과
김현영 ( Kim Hyun-Young )
서울대학교 의과대학 분당서울대학교병원 내과
박영수 ( Park Young-Soo )
서울대학교 의과대학 분당서울대학교병원 내과
김나영 ( Kim Na-Young )
서울대학교 의과대학 분당서울대학교병원 내과
정현채 ( Jung Hyun-Chae )
서울대학교 의과대학 내과학교실
송인성 ( Song In-Sung )
서울대학교 의과대학 내과학교실
KMID : 0359020110440020101
Abstract
Background/Aims: Eradication of Helicobacter pylori is widely accepted as initial therapy for low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, approximately 20% of patients with this disease are not responsive to H. pylori eradication therapy. The aim of this study was to assess remission and relapse rates of low-grade gastric MALT lymphoma after H. pylori eradication and identify the clinical factors that affect remission.
Methods: Thirty-nine patients diagnosed with gastric MALT lymphoma (May 2003 to May 2010) were retrospectively analyzed.
Results: Of the 39 patients, 30 (77%) had a H. pylori infection. There were 35/39 (90%) patients with stage I. Among stage I, 25 patients with the infection underwent eradication therapy and 22/25 (88%) achieved remission. The total regression rate with eradication only in stage I was 24/28 (86%). The median time to remission was 98 days (range, 22 to 397 days). Age, tumor location, invasion depth, H. pylori burden, and severity of mononuclear leukocyte and neutrophil infiltration were not related to remission. However, patients with less neutrophil infiltration were more likely to achieve a successful first H. pylori eradication (p=0.049).
Conclusion: The results show that the rate of low-grade gastric MALT lymphoma regression (86%) with H. pylori eradication alone was higher than that in Western studies (77.8%) and that neutrophil infiltration was inversely related to success of the first H. pylori eradication procedure.
키워드
Mucosa-associated lymphoid tissue; Lymphoma; Helicobacter pylori; Eradication; Remission
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