Comparison on the Efficacy of Disinfectants Used in Automated Endoscope Reprocessors: PHMB-DBAC versus Orthophthalaldehyde
김선영, 이홍식, 현종진, 서민호, 임선영, 오하영, 김혜숙, 금보라, 서연석, 김용식, 진윤태, 전훈재, 엄순호, 김창덕, 류호상,
소속 상세정보
김선영 ( Kim Sun-Young )
고려대학교 의과대학 내과학교실
이홍식 ( Lee Hong-Sik )
고려대학교 의과대학 내과학교실
현종진 ( Hyun Jong-Jin )
고려대학교 의과대학 내과학교실
서민호 ( Seo Min-Ho )
고려대학교 의과대학 내과학교실
임선영 ( Yim Sun-Young )
고려대학교 의과대학 내과학교실
오하영 ( Oh Ha-Young )
고려대학교 의과대학 내과학교실
김혜숙 ( Kim Hye-Sook )
고려대학교 의과대학 내과학교실
금보라 ( Keum Bo-Ra )
고려대학교 의과대학 내과학교실
서연석 ( Seo Yeon-Seok )
고려대학교 의과대학 내과학교실
김용식 ( Kim Yong-Sik )
고려대학교 의과대학 내과학교실
진윤태 ( Jeen Yoon-Tae )
고려대학교 의과대학 내과학교실
전훈재 ( Chun Hoon-Jai )
고려대학교 의과대학 내과학교실
엄순호 ( Um Soon-Ho )
고려대학교 의과대학 내과학교실
김창덕 ( Kim Chang-Duck )
고려대학교 의과대학 내과학교실
류호상 ( Ryu Ho-Sang )
고려대학교 의과대학 내과학교실
Abstract
Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical).
Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified.
Results: The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA.
Conclusion: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.
키워드
Endoscope reprocessing; Disinfectants; High-level disinfection
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