흰쥐에서 발정주기에 따른 자발적인 췌장외분비의 변화
Changes of spontaneous pancreatic exoerine secretion during the estrous cycle in rats
박형진, 이상목, 이덕윤, 이정우, 김계성,
소속 상세정보
박형진 ( )
한림대학교 의과대학 생리학교실
이상목 ( )
건양대학교 의과대학 생리학교실
이덕윤 ( )
건양대학교 의과대학 생리학교실
이정우 ( )
건양대학교 의과대학 생리학교실
김계성 ( )
서울대학교 수의과대학 생리학교실
KMID : 0359320000400040677
Abstract
Since the role of female sexual hormones on pancreatic exocrine secretion was not fully understood, this study was investigated to clarify the difference of spontaneous pancreatic exocrine responses during the estrous cycle and the roles of ovarian hormones on pancreatic exocrine secretion in the anesthetized female rats. Pancreatic juice was collected from the sequential 15-min samples, and then fluid and protein secretion were measured from the collected samples. The stages of estrous cycle were defined by staining the vaginal smear. The spontaneous pancreatic fluid and protein secretion were significantly increased during the diestrus stage compare to the corresponding value during the estrus stage. In the ovariectomized rat, spontaneous pancreatic exocrine secretion was significantly decreased compare to the value of female rat during the diestrus stage and was restored by subcutaneous injection of progesterone (50 ㎎/㎏). This results suggest that the spontaneous pancreatic exocrine secretion of female rat is fluctuated according to the estrous cycle and progesterone released from ovary could stimulate the spontaneous pancreatic exocrine secretion of female rat.
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