암 환자에서 연수막 전이 진단표지자로서의 뇌척수액 CYFRA 21-1
Cerebrospinal Fluid CYFRA 21-1 as a Diagnostic Indicator for Leptomeningeal Metastasis in Cancer Patients
현혜숙, 김선영, 신형식, 윤지영, 김소연, 김수현, 김종국, 정지향, 유헌, 곽호신, 김호진,
소속 상세정보
현혜숙 ( Hyun Hye-Sook )
국립암센터 신경과
김선영 ( Kim Sun-Young )
경희의료원 가정의학과
신형식 ( Shin Hyung-Shik )
국립암센터 진단검사의학과
윤지영 ( Yun Ji-Young )
이화여자대학교 의과대학 신경과학교실
김소연 ( Kim So-Yeon )
국립중앙의료원 진단검사의학과
김수현 ( Kim Su-Hyun )
국립암센터 신경과
김종국 ( Kim Jong-Kuk )
동아대학교 의과대학 신경과학교실
정지향 ( Jeong Jee-Hyang )
이화여자대학교 의과대학 신경과학교실
유헌 ( Yoo Heon )
국립암센터 뇌척수종양클리닉
곽호신 ( Gwak Ho-Shin )
국립암센터 뇌척수종양클리닉
김호진 ( Kim Ho-Jin )
국립암센터 신경과
Abstract
Background: The early and accurate diagnosis of leptomeningeal metastasis (LM) has become important because of introduction of new therapeutic strategies for LM and increasing incidence of LM along with longer survival of cancer patients. We aimed to evaluate the role of cerebrospinal fluid (CSF) CYFRA 21-1 as a diagnostic indicator for LM in patients with cancer.
Methods: CSF CYFRA 21-1 level was analyzed using electro-chemiluminescent immunoassay. The difference in concentration of CSF CYFRA 21-1 between 91 patients with LM and 339 control groups (patients with other neurological disease or healthy controls) was investigated. The cut-off value of CSF CYFRA 21-1 as a diagnostic indicator for LM and its diagnostic performance were evaluated.
Results: The CSF CYFRA 21-1 was significantly higher in LM patients than control groups (p<0.001). A cut-off value of diagnosis for LM in patients with cancer was 1.59 ng/mL. The sensitivity, specificity, accuracy, and positive and negative predictive values of CSF CYFRA 21-1 were 80.2%, 96.2%, 92.8%, 84.9%, 94.8% for diagnosis of LM.
Conclusions: These results suggested that CSF CYFRA 21-1 can be an additional diagnostic indicator for cancer patients with LM.
키워드
Neoplasm metastasis; Diagnosis; Cerebrospinal fluid; CYFRA 21-1
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