단일 기관에서 경험한 비기억상실형 경도 인지장애의 임상적 고찰
Clinical Characteristics of Non-Amnestic Mild Cognitive Impairment: A Single-Center Experien
오은, 신채원, 김범준, 황기은, 허성혁, 안태범, 장대일, 윤성상, 박기정, 이진산,
소속 상세정보
오은 ( Oh Eun )
경희대학교병원 신경과
신채원 ( Shin Chae-Won )
경희대학교병원 신경과
김범준 ( Kim Bum-Joon )
경희대학교병원 신경과
황기은 ( Hwang Ki-Eun )
경희대학교병원 신경과
허성혁 ( Heo Sung-Hyuk )
경희대학교병원 신경과
안태범 ( Ahn Tae-Beom )
경희대학교병원 신경과
장대일 ( Chang Dae-Il )
경희대학교병원 신경과
윤성상 ( Yoon Sung-Sang )
경희대학교병원 신경과
박기정 ( Park Key-Chung )
경희대학교병원 신경과
이진산 ( Lee Jin-San )
경희대학교병원 신경과
Abstract
Background: To evaluate the clinical characteristics of patients with non-amnestic mild cognitive impairment (naMCI) in a memory disorder clinic at a single center.
Methods: A retrospective study was conducted involving 312 patients with naMCI from May 2011 to July 2018. Brain magnetic resonance imaging and detailed neuropsychological tests were performed in all patients. We used the proposed criteria for naMCI to classify the patients into single- and multiple-domain groups. We compared the baseline clinical characteristics, neuroimaging findings, and the rate of progression to dementia between these two groups.
Results: The 312 patients comprised 210 in the single-domain group (67.3%) and 102 in the multiple-domain group (32.7%). The mean age was significantly higher in the multiple-domain group than in the single-domain group. The years of education, mean Mini Mental State Examination score, and mean Clinical Dementia Rating Scale Sum of Boxes score were significantly lower in the multiple-domain group than in the single-domain group. The Z-scores of neuropsychological tests in most cognitive domains were significantly lower in the multiple-domain group than in the single-domain group. Compared to the single-domain group, the multiple-domain group showed more-severe medial temporal atrophy and contained a higher proportion of patients with moderate white-matter hyperintensities. Thirteen (8.4%) patients with naMCI progressed to dementia, most of who were diagnosed with Alzheimer’s disease.
Conclusions: We present a single-center experience of clinical characteristics in patients with naMCI. Close observation of the clinical profiles of patients with naMCI may help identify individuals at the greatest risk of dementia.
키워드
Cognitive dysfunction; Dementia; Alzheimer disease
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