Radiosurgery에서 Intergrated Logistic Formula를 이용한 선량 조절
An Integrated Logistic Formula for Dose Prescription in Radiosurgery
소속 상세정보
박용구
정상섭/장진우/조준/김기홍
KMID : 0359819930220050659
Abstract
Radiation necrosis is the main obstacle for radiosurgery delivering high dose ionizing radiation inhomogeneoursly into small field of lesion with spatial accuracy. The complication probability is closely related to dose-volume effect. To reduce
the
complication rate, the optimum dose should be prescribed for the isodose curve enclosing the target lesion according to the lesion volume and isodose fall-off. However, the shape, volum and isodose fall-off of the lesions are different from each
other.
To choose the optimum doses for radiosurgery in each case, it is necessary to have a reasonable model for predicting dose-volume effects. Flickinger developed an integrated logistic formula using normalized total dose (NTD) as a reasonable model
to
predict complications from gamma knife radiosurgery. The authors developed a computer program to calculate the risk probability using that formula. As previously emphasized, the risk probability derived from the formula is useful and
indispensable
as a
guidance to dose prescription in gamma knife surgery.
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