Halothane 유도 산증이 국소성 뇌허혈증에 미치는 영향에 대한 실험적 연구
The Effect of Halothane induced Acidosis on Focal Cerebral Ischemia in Rat
한기수, 정학현, 최영철, 류경호,
소속 상세정보
한기수 ( )
고려대학교
정학현 ( )
고려대학교
최영철 ( )
고려대학교
류경호 ( )
고려대학교
KMID : 0359819930220080877
Abstract
The current study was performed to investigate the influence of acidosis on focal cerebral ischemia in view of morphometric assay and neuropathological examination. The acidosis was induced by increment of halothane concentration and by
decreasing
respiratory rate. The mean pH were 7.423±0.012 in control group and 7.184±0.038 in acidosis group. Twenty-four hours after MCA occlusion (MCAO). Neutral red staining and perfusion fixation was performed. The ischemic area was measured and
morphometric
analysis was undertaken. In acidosis group, the infarct area was 25.23±4.78% of the total cerebral area ; in control group, the infarct area was 27.69±4.05%. The histopathological findings were examined under light microscopy, in which the
ficld
scanning was carried out from the midline by 0.5mm interval at cortical and basal ganglia levels. These results indicated that although there was no satistically significant difference in infarct area between acidosis and control group, increased
acidosis aggravated the extent of histopathologic ischemic neuronal damage.
키워드
원문 및 링크아웃 정보
등재저널 정보