뇌종양에서 돌연변이형 p53단백 및 PCNA의 발현현상
Expression of p53 Protein and PCNA in Brain Tumors
소속 상세정보
김홍수
안영환/박언섭/목진호/박관/김영백/민병국/황성남/석종식
KMID : 0359819950240020189
Abstract
Formalin-fixed. paraffin-embedded samples of 32 brain tumors (8 meningiomas, 10 astrocytomas (low grade 5. anaplastic 5). 8 glioblastoma multiforme. 6 oligodendrogliomas (low grade 2. anaplastic 3) were investigated by immunocytochemistry with
monoclonal antibodies against p53 protein and proliferating cell nuclear antigen (PCNA).
Expression of p53 protein was detected in 1 of 5 cases (20%) of low grade astrocytomas. 2 of 5 cases (40%) of anaplastic astrocytoma. 4 of 8 cases (50%) of glioblastoma multiforme and 4 of 4 cases (100%) of malignant oligodendroglioma. All low
grade
oligodendrogliomas. meningiomas fail to express p53.
Expression of PCMA was detected in 3 of 8 cases of meningioma with very low labelling index (0-0.3). 2 of 5 cases of grade astrocytoma with low labelling index (1-11.3). 3 of 5 cases of anaplastic astrocytoma with middle labelling index (0-28.2).
6
of 8
cases of glioblastoma multiforme and 4 of 4 cases of malignant oligodendroglioma with high labelling index (0-92.3. 7.6-48.1). Expression of PCNA was not detected in low grade oligodendrogliomas.
Tumor group with high expression of p53 protein showed increment of PCNA expression. A strong positive correlation between tumor grade and extent of p53 protein and PCNA expression was found (p<0.002).
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