모래쥐(Gerbil)에서 지속적 및 간헐적 뇌혈류차단이 뇌부종과 허혈성 신경세포 손상에 미치는 영향
The Effects of Continuous and Intermittent Interruption of the Cerebral Blood Flow on Brain Edema and Ischemic Neuronal Injury in Gerbils
이진호, 주진양, 김원형, 김관세,
소속 상세정보
이진호 ( )
연세대학교
주진양 ( )
연세대학교
김원형 ( )
연세대학교
김관세 ( )
연세대학교
KMID : 0359819950240070753
Abstract
Temporary occlusion of the cerebral blood flow is an effective maneuver to prevent and/or to control excessive bleeding during neurosurgical operations Many studies have been reported employing single occlusion of various durations. However,
there
has
been only a few studies examing the consequences of repeated occlusions on the development of cerebral edema and neuronal injury in the gerbil. three separate episodes of 5-minute ischemia spaced at varied time interval was produced in Mongolian
gerbils
by occlusion of bilateral common carotid arteries. Quantitative estimates of cerebral edema and neuronal injury were obtained 24 hours after the third occlusion. The results was compared to that of single 15-minute occlusion.
In gerbils with three 5-minute occlusions at 10-minute intervals. cerebral edema was not significant. However, the animals killed 24 hours after three 5-minute occlusions at 1-hour intervals or single 15-minute occlusion showed severe cerebral
edema.
Such animals showed significantly more neuronal injury than in animals with three 5-minute occlusions at 10-minute intervals. These results suggest that ischemic brain damage may be reduced with repeated vascular occlusion spaced at short
intervals.
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