신경교종에서 FDG-양전자 방출 단층촬영에 의한 대사비와 조직학적 등급
Metabolic Ratio of FDG-PET and Histologic Grading in Cerebral Gliomas
소속 상세정보
신형진
김종현/이정일/김기준/조태구/신동익/김종수/홍승철/박관
KMID : 0359819970260040486
Abstract
결 론
1) FDG-PET 영상의 시각적 분석은 고등급 신경교종과 저등급 신경교종의 감별진단에
도움이 되었다.
2) FDG-FET를 이용한 종양과 소뇌의 대사비 측정은 교모세포종과 그 이외의 신경교종
의 감별진단에 도움이 되었는데 특히 고등급 신경교종중에서 교모세포종과 역형성 신경교종
의 감별진단에 도움이 되었다.
3) 뇌신경교종의 세포증식능의 한지표인 Ki-67치와 FDG-PET를 이용한 종양-소뇌간 대
사비는 좋은 상관관계를 보였다.
#초록#
To assess the degree of malignancy in cerebral gliomas at the time of diagnosis, we
compared the metable ratio using 18f-flurodeoxyglucose(FDG)-Position Emission
Tomography(PET) with histologic grading and proliferative index(Ki-67) of cerebral
gliomas.
Materials for this study were histologically-examined 21 gliomas and they were
divided into glioblastomas as group 1, anaplastic gliomas as group 2, and low-grade
gliomas as group 3.
The visual analysis of FDG-PET images showed hypermetabolic lesions in 14(87.5%)
out of 16 high-grade gliomas(glioblastomas and anaplastic gliomas), and hypermetabolic
lesions in 4(80%) out of 5 low-grade gliomas. Tumor to cerebellum ratio(T/Cbll) in
FDG-PET was used as metabolic ratio and the values of T/Cbll in each group were
1.30±0.10, 0.73±0.70, 0.70±0.07, respectively. In comparision of T/Cbll between group 1
with remaining two groups, differences were statistically significant(p=0.0002, p=0.0002,
respectively), however, there was no statistical difference between group 2 and group3.
The values of Ki-67 were 24.16±5.66 in group 1, 8.10±2.70 in group 2, 5.46±1.23 in
group 3, and differences were statistically significant between group 1 and group 2,
3(p=0.015, p=0.015, respectively), but there was no statistical difference between group 2
and group 3. The correlation between T/Cbll and Ki-67 was good and statistically
significant(p=0.0047)
In conclusion, the visual and semiquantitative analysis of FDG-PET would be helpful
in determining the degree of malignancy in cerebral gliomas.
키워드
Metabolic ratio; FDG-PET Histologic grading; Proliferative index.;
원문 및 링크아웃 정보
등재저널 정보