혼합성 신경효종의 치료에 대한 임싱결과
Clinical Outcome of the Mixed Glioma
소속 상세정보
최승진/Seung Jin Choi
이관성/홍용길/나형균/이상원/백민우/김문찬/강준기/Kwan Sung Lee/Yong Kil Hong/Hyung Kyun Rha/Sang Won Lee/Min Woo Baek/Moon Chan Kim/Joon Ki Kang.
KMID : 0359819980270121700
Abstract
결론
수술적 치료를 시행한 양성 희돌기성상세포종 3례와 역형성 희돌기성상세포종 7례에서 종
양적출의 정도와 수술후방사전치료 및 화학요법의 유무에 따른, 5개월에서 60개월간의 임상
경과와 예후에 대한 예비분석 결과 다음과 같은 결론을 내렸다
1) 종양의 진행이나 재발시에. 양성 및 역형성 희돌기성상세포종 모두에서 병리조직학적으
로 낮은 grade에서 높은 grade로, 혹은 더욱 심한 악성으로 전환되는 경우가 드물지 않을
것으로 생각된다.
2) 치료에 있어서는 양성 희돌기성상세포종의 경우 종양의 완전적출과 수술후 방사전치료,
역형성 희돌기성상세포종에서는 역시 종양의 완전적출과 방사선치료 및 화학요법, 특히
PCV 복합요법이 환자의 생존기간을 가장 많이 연장할 수 있으리라 사료된다.
#초록#
The author analyzed preliminary outcome of 10 patients with mixed glioma(3 patients
with low-grade oligoastrocytoma and 7 patients with anaplastic oligoastrocyma) who
underwent surgical resection and were treated or are in treatment with or without
adjuvant therapy at our institute since May 1993. In the low-grade oligoastrocytoma
group, gross total tumor resection was done in all three cases and postoperative
radiation therapy was performed in 2 cases. In the anaplastic oligoastrocytoma group, all
seven cases were divided as to the amount of tumor removal(gross total resection ; 4
cases, subtotal resection ; 1 case, partial resection ; 2 cases) and clinical course and
prognosis were analyzed as to performing postoperative radiation therapy with or
without chemotherapy. In the low-grade oligoastrocytoma group, one patient who didn't
undergo postoperative radiation therapy suffered from tumor recurrence that showed
histopathologically malignant transformation. In the anaplasic oligoastrocytoma group, 2
patients who underwent subtotal tumor resection and partial tumor resection with
postoperative radiation therapy showed tumor progression and histopathologically more
malignant transformation. The authors propose that gross total tumor resection with
postoperative radiation therapy in low-grade oligoastrocytoma and adding chemotherapy
appear to be a associate with more prolongation of patient's survival.
키워드
Low-grade oligoastrocytoma Anaplastic olisoastrocytoma; Gross total resection; Radiation therapy.;
원문 및 링크아웃 정보
등재저널 정보