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Abstract

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To clarify possible causes, pathogenesis, and appropriate prevention method of remote
intracerebral hemorrhage (RICH). we analyzed the clinical findings and the possible
predisposing factors of six cases who developed RICH among the 206 surgical series of
cerebral aneurysm operated in our hospital over recent 5-year period. The locations of
aneurysm were anterior communicating artery in three cases and internal carotid artery
in three ocher cases. The sites of RICH were dependent regions considering the
operative position in five of six cases, contralateral cerebellum in three cases, bilateral
cerebellum in one case, and contralateral occipital area in one case. Peripheral low
density around the RICH, suggesting hemorrhagic infarction, was observed on computed
tomography in four cases. No patient had preoperative hypertension : however significant
elevation of blood pressure was observed intraoperatively or postoperatively in three
cases. The factors which could have induced brain shift(large amount of removed or
drained cerebrospinal fluid, large amount of infused mannitol, too low
PaCO2) were observed in all cases except one case. There was no case
wish coagulopathy or underlying occult lesion. Two patients in whom detection of RICH
was delayed showed poor outcomes.
The possible underlying mechanisms involved in such complication seem to bs shifting
of brain doe to sudden decreased intracranial pressure and excessive removal of
cerebrospinal fluid, and subsequent injury of blood vessels such as compression or
breakdown of vein. Moreover the sudden elevation of blood pressure may have played a
role as contributing factor. Therefore, consideration should be given to the maintenance
of an adequate volume of intracranial cerebrospinal fluid and the appropriate blood
pressure to prevent this complication. Early detection and immediate treatment with
awareness of the possibility of this complication should be borne in mind when treating
these patients to prevent such complications anti to obtain good results.

Å°¿öµå

Cerebral aneurysm; Surgery; Complication; Hemorrhage; Remote;

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