수모세포종의 Isochromosome 17q와 예후에 관한 연구
Medulloblastoma : Does the Isochromosome 17q Influence on the Long Term Survival?
소속 상세정보
남도현/Do Hyun Nam
왕규창/김승기/지제근/김연미/조병규/Kyu Chang Wang/Seung Ki Kim/Je Geun Chi/Youn Mi Kim/Byung Kyu Cho
KMID : 0359819990280091312
Abstract
결론
수모세포종에서 i(17q)의 발생 빈도는 53%로 수모 세포종의 발생과 관련이 있을 것으로
사료되나 예후와는 관계가 없었다. 향후 수모세포종의 예후와 관련하여 c-erbB-2
on-cogene, bcl-2, apoptosis, p53의 발현과 세포증식능력등이 장기간 추적한 환자의 재발에
미치는 영향을 평가하여야 할 것으로 사료된다.
#초록#
Objective : An isochromosome for the long arm of 17, i(17q), is the most frequent
chromosomal abnormality in medulloblastoma. occurring in 30-50% of cases by
karyotype analysis and this abnormality has been reported to be present in cases with a
shorter survival time by some authors. Moleculogenetic analysis for i(17q) was
performed to identify its influence on the long term survival.
Patients and Methods : The authors reviewed 17 children and divided them into two
groups(favorable and poor outcomes) to elucidate the influence of the i(17q) on the long
term survival. Eight children with favorable outcome are in disease-free status during
the follow-up period(range : 52-87 months. median : 85 months). The other nine
children with poor outcome died of disease progression or recurrence and their median
survival time was 19 months (range 1-28 months). Fluorescent in situ hybridization
(FISH) was used for the detection of i(17q) in 17 children.
Results : The i(17q) was detected in nine of 17 children. There was no difference in
the positive rates of i(17q) between two groups.
Conclusion : The i(17q) was detected by FISH in 53% of medulloblastoma patients.
presence of the i(17q) was not a prognostic factor on the long term survival.
키워드
Medulloblastoma; Isochromosome 17q; Prognosis;
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