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Mitomycin C¸¦ º´¿ëÇÑ ¼¶À¯ÁÖÀýÁ¦¼ú ÈÄ Ç÷¾×¹æ¼öÀ庮ÀÇ ¼Õ»ó°üÂû Observation of Damage to the Blood-Aqueous Barrier after Trabeculectomy with Mitomycin C

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Á¤Çмº/Hak Sung Chung ÀÌ¿µ±â/¹ÚÇý¼º/È«¿µÀç/Á¤Çмº/ÀÌ¿µ±â/¹ÚÇý¼º/È«¿µÀç/Young Ghee Lee/Hae Song Park/Young Jae Houng/Hak Sung Chung/Young Ghee Lee/Hae Song Park/Young Jae Houng

Abstract

-¿ä¾à-
º» ¿¬±¸¿¡¼­´Â MMC¸¦ º´¿ëÇÑ ¼¶À¯ÁÖÀýÁ¦¼úÀ» ½ÃÇà¹ÞÀº ȯÀÚ¿¡¼­ laser flaremeter¸¦ ÀÌ¿ë
ÇÏ¿© Àü¹æ³» È帲(flats)¸¦ ÃøÁ¤ÇÔÀ¸·Î½á MMC°¡ Ç÷¾×¹æ¼öÀ庮¿¡ ¼Õ»óÀ» ÁÖ´Â Áö¸¦ ¾Ë¾Æº¸
°íÀÚ ÇÏ¿´´Ù. 1995³â 5¿ùºÎÅÍ 1997³â 1¿ù±îÁö ¿ø¹ß°³¹æ°¢³ì³»ÀåÀ¸·Î Áø´Ü¹Þ°í ¼¶À¯ÁÖÀýÁ¦¼ú
À» ½ÃÇà¹ÞÀº ȯÀÚ¸¦ ´ë»óÀ¸·Î ÇÏ¿´´Ù. 10¸í 11¾ÈÀº MMC¸¦ »ç¿ëÇÏÁö ¾Ê°í, 9¸í 11¾È¿¡´Â
°ø¸·ÆíÀ§·Î 0.02% MMC¸¦ 3ºÐ°£ Àû¿ëÇÏ¿´´Ù. ¼ö¼úÀü°ú ¼ö¼úÈÄ 1ÀÏ, 1ÁÖ, 1°³¿ù, 2°³¿ù, 3°³
¿ù¿¡ Àü¹æ³» È帲°ú ¾È¾ÐÀ» ÃøÁ¤ÇÏ¿´´Ù. ¼ö¼úÀü°ú ¼ö¼úÈÄ 1ÀÏ, 3°³¿ù¿¡ Àü¹æ³» È帲ÀÌ
MMC¸¦ »ç¿ëÇÑ ±ºÀº 10.8¡¾5.05, 15.6¡¾5.32, 10.1¡¾4.55(photon count/msec)À̾ú°í, »ç¿ëÇÏÁö
¾ÊÀº ±ºÀº 10.6¡¾4.04, 15.9¡¾3.30, 9.2¡¾3.94(photon count/msec)À̾ú´Ù. µÎ ±º ¸ðµÎ¿¡¼­ ¼ö¼ú
ÈÄ 1ÀÏ¿¡ Àü¹æ³» È帲ÀÌ ÃÖ°íÄ¡¸¦ º¸¿´À¸¸ç, ¼ö¼úÈÄ 1°³¿ù¿¡´Â ¼ö¼úÀü ¼öÁØÀ¸·Î ȸº¹µÇ¾ú´Ù.
±×·¯³ª µÎ ±º »çÀÌ¿¡ ÀǹÌÀÖ´Â Â÷ÀÌ´Â º¸ÀÌÁö ¾Ê¾Ò´Ù(p>0.05). ¼¶À¯ÁÖÀýÁ¦¼úÈÄ Àü¹æ³» È帲
ÀÌ Áõ°¡ÇÏ°í ½Ã°£ÀÌ °æ°úÇÔ¿¡ µû¶ó ¼ö¼úÀü ¼öÁØÀ¸·Î ȸº¹µÈ °ÍÀº ¼ö¼ú·Î ÀÎÇÑ Ç÷¾×¹æ¼öÀ庮
ÀÇ ¼Õ»óÀ» °£Á¢ÀûÀ¸·Î º¸¿©ÁØ´Ù. ±×·¯³ª µÎ ±º »çÀÌ¿¡ À¯ÀÇÇÑ Â÷ÀÌ°¡ ¾ø´Â °ÍÀ¸·Î ¹Ì·ç¾î
º¼ ¶§, ¼ö¼ú½Ã Àû¿ëÇÏ´Â 0.02% MMC´Â Ç÷¾×¹æ¼öÀ庮¿¡ ¸¹Àº ¼Õ»óÀ» ÃÊ·¡ÇÏÁö´Â ¾ÊÀ» °ÍÀ¸·Î »ý°¢µÈ´Ù.
#ÃÊ·Ï#
We observed the breakdown of the blood-aqueous barrier after trabeculectomy with
mitomycin C by using laser flaremeter. There were 20 patients(25 eyes) of which 9
patients(11 eyes) were applied 0.02% MMC for 3 minutes during the trabeculectomy and
11 patients(14 eyes) were not applied MMC. All patients were diagnosed as primary
open angle glaucoma and underwent trabeculectomy. The preoperative, postoperative 1
day and 3 months aqueous flare intensity were 10.8¡¾5.05, 15.6¡¾5.32, 10.1¡¾4.55 (photon
count/msec) in group with MMC and 10.6¡¾4.04, 15.9¡¾3.30, 9.2¡¾3.94(photon count/msec)
in group without MMC. Anterior chamber flares were highest on the first postoperative
day, declining rapidly in the first week with more gradual recovery to preoperative level
by 1 month postoperatively, which shows the breakdown of blood-aqueous barrier by
surgery. There was no statistically significant difference between the two groups in
postsurgical aqueous flare intensity. 0.02% MMC does not appear to have much
influence on the breakdown of blood-aqueous barrier.

Å°¿öµå

Mitomycin C; Trabeculectomy; Blood aqueous barrier; Laser flaremeter;

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