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A Case of Clozapine-induced Corneal and Lenticular Pigmentation
¾ÈÁö¼±, ÀÌ¿µ¹Ì, °ûÁÖ¿µ, ÇöÁÖ, ÃÖÁø¼®, ¹Ú±ÔÈ«, Á¤¼º±Ù,
¼Ò¼Ó »ó¼¼Á¤º¸
¾ÈÁö¼± ( An Ji-Seon )
»õºû¾È°úº´¿ø
ÀÌ¿µ¹Ì ( Lee Young-Mi )
»õºû¾È°úº´¿ø ¾àÁ¦½Ç
°ûÁÖ¿µ ( Kwag Joo-Young )
»õºû¾È°úº´¿ø
ÇöÁÖ ( Hyun Joo )
»õºû¾È°úº´¿ø
ÃÖÁø¼® ( Choi Jin-Seok )
»õºû¾È°úº´¿ø
¹Ú±ÔÈ« ( Pak Kyu-Hong )
»õºû¾È°úº´¿ø
Á¤¼º±Ù ( Chung Sung-Kun )
»õºû¾È°úº´¿ø
Abstract
¸ñÀû: Àå±â°£ Ŭ·ÎÀÚÇÉÀ» º¹¿ëÇÑ È¯ÀÚ¿¡¼ °¢¸·°ú ¼öÁ¤Ã¼ÀÇ »ö¼ÒħÂø 1¿¹¸¦ º¸°íÇÏ°íÀÚ ÇÑ´Ù.
Áõ·Ê¿ä¾à: Á¶Çöº´À» ¾Î°í ÀÖ´Â 56¼¼ ³²ÀÚ°¡ ¾ç¾ÈÀÇ ½Ã·ÂÀúÇϸ¦ ÁÖ¼Ò·Î ³»¿øÇÏ¿´´Ù. ȯÀÚ´Â 5³â°£ ¸ÅÀÏ Å¬·ÎÀÚÇÉ 200 mg, ·Î¶óÁ¦ÆÊ 1 mgÀ» º¹¿ëÇÏ¿´´Ù. ù ³»¿ø ½Ã ¾ç¾È ÃÖ´ë ±³Á¤½Ã·ÂÀº ¾ç¾È 20/32¿´´Ù. ¼¼±Øµî°Ë»ç¿¡¼ ¾ç¾È °¢¸·³»ÇǼ¼Æ÷Ãþ¿¡ ¹à°í ¹Ì¼¼ÇÑ È¸°¥»öÀÇ Ä§Âø¹°ÀÌ °üÂûµÇ¾ú°í, »êµ¿ ÈÄ ¼öÁ¤Ã¼ Àü³¶¾Æ·¡ ¹æ»ç¼±»óÀÇ »ö¼ÒħÂøÀÌ Á߾Ӻο¡ °üÂûµÇ¾ú´Ù.
°á·Ð: Ŭ·ÎÀÚÇÉÀÇ º¹¿ëÀº °¢¸·°ú ¼öÁ¤Ã¼¿¡ »ö¼ÒħÂøÀ» À¯¹ßÇϸç, ½Ã·ÂÀúÇϸ¦ ÀÏÀ¸Å²´Ù. ¾ÕÀ¸·Î Àå±â°£ÀÇ Å¬·ÎÀÚÇÉ º¹¿ë Ä¡·á¸¦ ¹Þ´Â ȯÀÚ´Â Á¤±âÀûÀÎ ¾È°ú °ËÁøÀ» °í·ÁÇØ¾ß ÇÒ °ÍÀÌ´Ù.
Purpose: To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy.
Case summary: A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed.
Conclusions: Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review.
Å°¿öµå
Clozapine; Corneal pigmentation; Lenticular pigmentation
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