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¸Á¸·´ëµ¿¸Æ·ù¿¡ ÇÕº´µÈ Ȳ¹ÝÃâÇ÷ȯÀÚ¿¡¼­ º£¹Ù½ÃÁÖ¸¿ ´Üµ¶ Ä¡·áÀÇ ÀÓ»ó¾ç»ó Bevacizumab Monotherapy for Macular Hemorrhage Secondary to a Retinal Arterial Macroaneurysm

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±èÁö¼ö, äÁÖº´, ±èÁø¿µ, Çü¼º¹Î, ±èµ¿À±,
¼Ò¼Ó »ó¼¼Á¤º¸
±èÁö¼ö ( Kim Ji-Soo ) 
Chungbuk National University

äÁÖº´ ( Chae Ju-Byung ) 
Chungbuk National University
±èÁø¿µ ( Kim Jin-Young ) 
Á¦ÁÖ´ëÇб³ ÀÇ°ú´ëÇÐ Á¦ÁÖ´ëÇб³º´¿ø ¾È°úÇб³½Ç
Çü¼º¹Î ( Hyung Sung-Min ) 
Chungbuk National University
±èµ¿À± ( Kim Dong-Yoon ) 
Chungbuk National University

Abstract

¸ñÀû: ¸Á¸·´ëµ¿¸Æ·ù(retinal arterial macroaneurysm)¿¡ ÇÕº´µÈ Ȳ¹ÝÃâÇ÷(submacular or subinternal limiting membrane hemorrhage) ȯÀÚ¿¡¼­ À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ ÁÖ»ç ´Üµ¶ Ä¡·áÀÇ ÀÓ»ó¾ç»óÀ» ºÐ¼®ÇÏ°íÀÚ ÇÑ´Ù.

´ë»ó°ú ¹æ¹ý: ¸Á¸·´ëµ¿¸Æ·ù¿¡ ÇÕº´µÈ Ȳ¹ÝÃâÇ÷·Î À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ Áֻ縦 ½ÃÇàÇÑ È¯ÀÚ(17¸í 17¾È)¸¦ ´ë»óÀ¸·Î ÈÄÇâÀû Àǹ«±â·ÏÁ¶»ç¸¦ ½ÃÇàÇÏ¿´´Ù. À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ ÁÖ»ç Ä¡·á ÀÌÈÄ ½Ã·Â°³¼± Á¤µµ, Á߽ɸÁ¸·µÎ²² º¯È­ µîÀ» ºÐ¼®ÇÏ¿´´Ù. 1 logMAR ½Ã·ÂÀ» ±âÁØÀ¸·Î Ä¡·á ÈÄ ½Ã·ÂÀÌ ÁÁÀº ±º°ú ³ª»Û ±ºÀ¸·Î ³ª´©¾î ºñ±³ ºÐ¼®ÇÏ¿´´Ù.

°á°ú: ¸Á¸·´ëµ¿¸Æ·ù¿¡ ÇÕº´µÈ Ȳ¹ÝÃâÇ÷·Î À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ Ä¡·á¸¦ ½ÃÇà¹ÞÀº ȯÀÚ(17¸í 17¾È)ÀÇ Æò±Õ ³ªÀÌ´Â 78.47 ¡¾ 7.84¼¼¿´´Ù. Æò±Õ °æ°ú °üÂû ±â°£Àº 3.99 ¡¾ 2.99°³¿ùÀ̾úÀ¸¸ç, Æò±Õ º£¹Ù½ÃÁÖ¸¿ ÁÖ»ç Ƚ¼ö´Â 2.12 ¡¾ 1.36ȸ¿´´Ù. À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ Ä¡·á ÈÄ ÀÇ¹Ì ÀÖ´Â ½Ã·ÂÈ£Àü°ú Á߽ɸÁ¸·µÎ²²ÀÇ °¨¼Ò°¡ ÀÖ¾úÀ¸¸ç, Ä¡·á ÀÌÈÄ ½Ã·Â¿¹ÈÄ°¡ ÁÁÀº ±º¿¡¼­´Â Áõ»óÀÇ ½ÃÀÛºÎÅÍ Ä¡·á ½ÃÀÛ±îÁöÀÇ ±â°£ÀÌ Âª¾Ò´Ù.

°á·Ð: ¸Á¸·´ëµ¿¸Æ·ù¿¡ ÇÕº´µÈ Ȳ¹ÝÃâÇ÷ȯÀÚ¿¡¼­ À¯¸®Ã¼°­³» º£¹Ù½ÃÁÖ¸¿ ÁÖ»ç ´Üµ¶ Ä¡·á´Â ½Ã·Â °³¼±°ú Á߽ɸÁ¸·µÎ²²ÀÇ °¨¼Ò¿¡ ÀÖ¾î ÁÁÀº °á°ú¸¦ º¸¿´À¸¸ç, Ä¡·á¸¦ »¡¸® ½ÃÀÛÇÏ¿© ÁÁÀº ½Ã·Â¿¹Èĸ¦ º¸¿´´Ù.

Purpose: To evaluate the clinical features of intravitreal bevacizumab injection in patients with macular hemorrhage (submacular or subinternal limiting membrane hemorrhage) secondary to a retinal arterial macroaneurysm.

Methods: We retrospectively reviewed the medical records of 17 eyes of 17 patients who underwent intravitreal bevacizumab injection with macular hemorrhage secondary to retinal arterial macroaneurysm. We evaluated the improvement of visual acuity and changes in central retinal thickness after intravitreal injections of bevacizumab. According to the final visual acuity, the characteristics of the good and poor visual prognoses groups were compared.

Results: The mean age of patients (17 eyes) who underwent intravitreal bevacizumab treatment for macular hemorrhage secondary to retinal arterial macroaneurysm was 78.47 ¡¾ 7.84 years. The mean follow-up period was 3.99 ¡¾ 2.99 months, and the mean number of injections of bevacizumab was 2.12 ¡¾ 1.36. There were significant improvements in visual acuity and central retinal thickness, and the duration from symptom onset to treatment was shorter in patients with good visual prognoses.

Conclusions: Intravitreal bevacizumab injection alone was effective for improving visual acuity and decreasing central retinal thickness in patients with macular hemorrhage secondary to retinal arterial macroaneurysms.

Å°¿öµå

Bevacizumab; Retina; Retinal arterial macroaneurysm; Retinal hemorrhage; Visual acuity

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