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³× °¡Áö ºû°£¼·´ÜÃþÇ÷°üÁ¶¿µ¼ú ±â±âÀÇ ¸Á¸·Ç÷°ü ¹Ðµµ¿Í ¸Á¸·Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§ÀÇ Å©±â ºÐ¼® Analyses of Vessel Densities and Foveal Avascular Zones Using Four Optical Coherence Tomography Angiography Devices

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¹Ú¼­¿¬, ³²±âÅÂ, À±Ã¶¹Î, À强¹Î,
¼Ò¼Ó »ó¼¼Á¤º¸
¹Ú¼­¿¬ ( Park Seo-Yeon ) 
Korea University College of Medicine Department of Ophthalmology

³²±âÅ ( Nam Ki-Tae ) 
Korea University College of Medicine Department of Ophthalmology
À±Ã¶¹Î ( Yun Cheol-Min ) 
Korea University College of Medicine Department of Ophthalmology
À强¹Î ( Jang Sung-Min ) 
Korea University College of Medicine Department of Ophthalmology

Abstract

¸ñÀû: ³× °¡Áö ´Ù¸¥ ºû°£¼·´ÜÃþÇ÷°üÁ¶¿µ¼ú ¿µ»óÀÇ ¸Á¸·Ç÷°ü ¹Ðµµ ¹× ¸Á¸·Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§¸¦ ºñ±³ÇÏ°íÀÚ ÇÏ¿´´Ù.

´ë»ó°ú ¹æ¹ý: ÀüÇâÀû ¿¬±¸·Î, °Ç°­ÇÑ ¼ºÀÎÀ» ´ë»óÀ¸·Î Plex-Elite (Carl Zeiss), DRI OCT-1 Atlantis (Topcon), AngioPlex (Carl Zeiss), Spectralis OCTA (Heidelberg) ±â±â¸¦ ÀÌ¿ëÇÏ¿© ¾òÀº Ȳ¹Ý Á᫐ 3 x 3 mm2 ¿µ»óÀÇ ¸Á¸·Ç÷°ü ¹Ðµµ¿Í Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§ÀÇ Å©±â¸¦ ºÐ¼®ÇÏ¿´´Ù.

°á°ú: Ç¥Ãþ ¹× ½ÉºÎ¸ð¼¼Ç÷°üÃÑÀÇ ¸Á¸·Ç÷°ü ¹Ðµµ(%)´Â Plex-Elite (42.17 ¡¾ 2.79, 43.71 ¡¾ 2.36), DRI OCT-1 Atlantis (28.70 ¡¾ 2.87, 30.27 ¡¾ 3.02), AngioPlex (28.32 ¡¾ 6.68, 33.33 ¡¾ 5.44), Spectralis OCTA (27.86 ¡¾ 4.13, 28.54 ¡¾ 3.14)·Î, ±â±â °£ Â÷ÀÌ°¡ ÀÖ¾ú°í(p<0.001), Ç¥Ãþ ¹× ½ÉºÎ¸ð¼¼Ç÷°üÃÑÀÇ Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§ÀÇ Å©±â(mm2)´Â °¢°¢ Plex-Elite (0.276 ¡¾ 0.097, 0.340 ¡¾ 0.100), DRI OCT-1 Atlantis (0.281 ¡¾ 0.102, 0.354 ¡¾ 0.119), AngioPlex (0.269 ¡¾ 0.099, 0.422 ¡¾ 0.120), Spectralis OCTA (0.272 ¡¾ 0.079, 0.298 ¡¾ 0.106)·Î, ±â±â °£ Â÷À̸¦ º¸¿´´Ù(p<0.001). Ç¥Ãþ ¹× ½ÉºÎ¸ð¼¼Ç÷°üÃÑ ¸Á¸·Ç÷°ü ¹Ðµµ ¸ðµÎ ³× °¡Áö ±â±â °£ À¯ÀÇÇÑ »ó°ü°ü°è¸¦ º¸ÀÌÁö ¾Ê¾ÒÀ¸³ª(p>0.05), ¸Á¸·Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§ ¸éÀûÀº Ç¥Ãþ ¹× ½ÉºÎ¸ð¼¼Ç÷°üÃÑ ¸ðµÎ¿¡¼­ ³× °¡Áö ±â±â °£ÀÇ Åë°èÀûÀ¸·Î À¯ÀÇÇÑ ¾çÀÇ »ó°ü°ü°è¸¦ º¸¿´´Ù(p<0.001).

°á·Ð: ³× °¡Áö ºû°£¼·´ÜÃþÇ÷°üÁ¶¿µ¼ú ±â±â¸¦ ÀÌ¿ëÇÑ ¸Á¸·Ç÷°ü ¹Ðµµ¿Í ¸Á¸·Á߽ɿÀ¸ñ¹«Ç÷°üºÎÀ§ ¸éÀûÀº ±â±â °£ Â÷ÀÌ°¡ ÀÖ¾úÀ¸¸ç, ¿µ»óÀ» ºÐ¼®ÇÏ´Â µ¥ ÀÖ¾î ÀÌ·¯ÇÑ Â÷À̸¦ °í·ÁÇØ¾ß ÇÒ °ÍÀ¸·Î ÆǴܵȴÙ.

Purpose: To compare the vessel density (VD) and foveal avascular zone (FAZ) area using four different optical coherence tomography angiography (OCTA) images.

Methods: This prospective study analyzed the OCTA images of consecutive healthy subjects using Plex-Elite (Carl Zeiss), DRI OCT-1 Atlantis (Topcon), AngioPlex (Carl Zeiss), and Spectralis OCTA (Heidelberg Engineering). The VD and FAZ areas were calculated using the OCTA images with a 3 x 3 mm2 volume scan pattern centered on the fovea.

Results: The VD (%) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were different using the four devices: Plex-Elite (42.17 ¡¾ 2.79, 43.71 ¡¾ 2.36), DRI OCT-1 Atlantis (28.70 ¡¾ 2.87, 30.27 ¡¾ 3.02), AngioPlex (28.32 ¡¾ 6.68, 33.33 ¡¾ 5.44), and Spectralis OCTA (27.86 ¡¾ 4.13, 28.54 ¡¾ 3.14), respectively; p < 0.001). The FAZ area (mm2) of the SCP and DCP were different using the four devices: Plex-Elite (0.276 ¡¾ 0.097, 0.340 ¡¾ 0.100), DRI OCT-1 Atlantis (0.281 ¡¾ 0.102, 0.354 ¡¾ 0.119), AngioPlex (0.269 ¡¾ 0.099, 0.422 ¡¾ 0.120), and Spectralis OCTA (0.272 ¡¾ 0.079, 0.298 ¡¾ 0.106), respectively; p < 0.001). The VD of the SCP and DCP had no significant correlation using the four devices (all, p > 0.05), but the FAZ area had positive correlations using the four devices (all, p < 0.001).

Conclusions: The four OCTA devices provided different VD and FAZ areas, so these differences should be considered in analyzing OCTA images.

Å°¿öµå

Foveal avascular zone; Optical coherence tomography angiography; Vessel density

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