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Quantification of Vascular Tortuosity by Analyzing Smartphone Fundus Photographs in Patients with Retinopathy of Prematurity
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±èÁ¾¼ö ( Kim Jong-Soo )
Dong-A University College of Medicine Department of Ophthalmology
¾È¼ºÇö ( An Seoung-Hyun )
Dong-A University College of Medicine Department of Ophthalmology
±èÀ±°æ ( Kim Yun-Kyung )
Dong-A University College of Engineering Department of Electronics Engineering
±ÇÀ±Çü ( Kwon Yoon-Hyung )
Dong-A University College of Medicine Department of Ophthalmology
Abstract
Purpose: To determine the usefulness of measuring the tortuosity of retinal arteries using smartphone fundus photographs to quantify plus disease in retinopathy of prematurity (ROP) patients.
Methods: Digital fundus photographs were taken with a smartphone of 116 eyes involving 58 premature infants. The tortuosity of retinal arteries named as the tortuosity index (TI) was measured with Image J software. Patients were classified into the treated and control groups and the TIs of the two groups were compared. A receiver operating characteristic curve was constructed and areas under the curve (AUC) were calculated to quantify the diagnostic utility of TI.
Results: Fundus photographs of 98 eyes of 50 premature infants were analyzed; 38 eyes of 20 infants were the treated group and 60 eyes of 30 infants were the control group. The TI was 1.231 ¡¾ 0.156 in the treated group before treatment, which was significantly larger than 1.062 ¡¾ 0.019 in the control group. After treatment of the treated group, the TI was 1.100 ¡¾ 0.093, which was significantly smaller than before treatment. The AUC was 0.926, and using a cut-off value of 1.095, the sensitivity and specificity of TIs for requiring treatment were 85.1% and 95.5%, respectively.
Conclusions: The tortuosity of retinal arteries was measured by analyzing smartphone fundus photographs to quantify plus disease in ROP patients. This method may be helpful for screening, follow-up, and treatment decisions for ROP patients.
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Plus disease; Retinopathy of prematurity; Smartphone; Vascular tortuosity
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