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Efficacy of Preservative-free Latanoprost in Normal-tension Glaucoma with Mild to Moderate Dry Eye
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À̼۹Π( Lee Song-Min )
Dong-A University College of Medicine Department of Ophthalmology
Áø»ó¿í ( Jin Sang-Wook )
Dong-A University College of Medicine Department of Ophthalmology
Abstract
Purpose: To evaluate the efficacy and safety of preservative-free latanoprost in patients with normal-tension glaucoma who had mild to moderate dry eye after switching from preserved latanoprost.
Methods: This retrospective study was conducted in patients with normal-tension glaucoma who had mild to moderate dry eye. All enrolled patients had used preserved latanoprost and switched to preservative-free Latanoprost. The study consisted of a baseline visit (treatment with preserved latanoprost) and four follow-up visits conducted after 1, 3, 6, and 12 months of treatment with preservative-free latanoprost. Intraocular pressure (IOP), mean deviation (MD), ocular surface disease index (OSDI), Shirmer¡¯s test score, tear break-up time (TBUT), corneo-conjunctival fluorescein staining, and adverse drug reactions were evaluated.
Results: The mean IOP and MD values during treatment with preserved latanoprost were 14.1 ¡¾ 2.6 mmHg and -2.68 ¡¾ 0.11 dB, respectively. The mean IOP and MD values at 12 months after switching to preservative-free latanoprost were 13.9 ¡¾ 1.9 mmHg and -2.66 ¡¾ 0.12 dB, respectively. The OSDI, Shirmer¡¯s test score, BUT, and corneo-conjunctival fluorescein staining during treatment with preserved latanoprost were 53.15 ¡¾ 8.86, 4.97 ¡¾ 1.71 mm, 4.92 ¡¾ 1.72 seconds, and 2.92 ¡¾ 1.05, respectively. The OSDI, Shirmer¡¯s test score, TBUT, and corneo-conjunctival fluorescein staining at 12 months after switching to preservative-free latanoprost were 49.07 ¡¾ 6.97, 5.51 ¡¾ 1.48 mm, 5.49 ¡¾ 1.46 seconds, and 2.47 ¡¾ 1.09, respectively. There were no serious adverse drug reactions causing ocular damage.
Conclusions: Preservative-free latanoprost was effective for improving objective and subjective symptoms compared to preserved latanoprost; it maintained a stable IOP and visual field value in patients with normal-tension glaucoma who had mild to moderate dry eye.
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Dry eye; Normal tension glaucoma; Monoprost ¢ç; Preservative free latanoprost
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