Lyophyllum decastes의 抗癌成分의 免疫學的 硏究(II)
Immunological Studies on the Antitumor Component of Lyophyllum decastes (II)
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李廷玉/Lee, Chong Ock
崔應七/金炳珏/Choi, Eung Chil/Kim, Byong Kak
KMID : 0360319870190020057
Abstract
Lyophyllan A was isolated as an antitumor component from Lyophyllum decastes. To elucidate mechanisms of its antitumor activity, its effects on immune response were examined. Lyophyllan A restored the suppressed delayed-type hypersensitivity reaction in tumor-bearing mice up to 85. 7% of the normal level. Also lyophyllan A enhanced in vivo generation of cytotoxic T-lymphocytes. When effects of lyophyllan A on natural killer cells that are one of the important nonspecific effector cells were examined, it augmented natural killer activity in the spleen cells of mice. These results showed that lyophyllan A is an immunopotentiator.
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