대장암에 대한 5-Fluorouracil 지속주입 및 Mitomycin-C(FM) 복합화학요법의 치료효과
5-Fluorouracil Continuous Infusion and Mitomycin-C (FM) Combination Chemotherapy for Metastatic or Recurrent Colorectal Cancer
대한암학회지 1987년 19권 2호 p.101 ~ 106
강윤구, 윤성수, 이재훈, 김승택, 방영주, 김노경, 박재감,
소속 상세정보
강윤구 ( )
서울대학교 의과대학 내과학교실
윤성수 ( )
서울대학교 의과대학 내과학교실
이재훈 ( )
서울대학교 의과대학 내과학교실
김승택 ( )
서울대학교 의과대학 내과학교실
방영주 ( )
서울대학교 의과대학 내과학교실
김노경 ( )
서울대학교 의과대학 내과학교실
박재감 ( )
서울대학교 의과대학 외과학교실
KMID : 0360319870190020101
Abstract
Between March, 1983 and June, 1986, 64 patients with metastatic or recurrent colorectal cancer were treated with a combination chemotherapy consisting of 5-fluorouracil (5-FU), 1,000 mg/㎡ iv continuous infusion over 12 hours on day 1-5; mitomycin-C, 10 mg/㎡ iv on day 1; cycled every 4 weeks. Among 46 patients with measurable lesions, none achieved complete remission and 5 (11%) achieved partial remissions. The median duration of remission was 31 weeks. Overall median survival was 49 weeks for all patients; 65 weeks for patients with remission; 51 weeks for those with stable disease; and 31 weeks for those with progressive disease. Greater response rates were observed in patient groups with age over 50, performance status 0-1, no previous history of chemotherapy, initial CEA level less than 10 ng/ml, or metastatic sites of lymph node, than in respective comparative patient groups. But, these differences did not achieved statistical significance. Toxicity was common, but generally mild to moderate and rapidly reversible.
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