The Promoting Effect of Capsaicin on the Development of Diethylnitrosamine-initiated Enzyme Altered Hepatic Foci in Male Sprague-Dawley Rats
장자준, 김성호,
소속 상세정보
장자준 ( Jang Ja-June )
Korea Cancer Center Hospital Department of Anatomical Pathology
김성호 ( Kim Sung-Ho )
Laboratory of Cancer Pathology Korea Cancer Center Hospital
KMID : 0360319880200010001
Abstract
The modification potentials of capsaicin on the development of immunohistochemical glutathione S-transferase (placental type) positive (GST-P^(+)) liver cell foci were examined in an in vivo mid-term assay system. Rats were given a single intraperitoneal injection of diethylnitrosamine (DEN) and then 0.002% capsaicin in drinking water (Group 1) or tap water (Group 2) from week 2 till termination in week 8. All rats of groups 1 and 2 were subjected to two-thirds partial hepatectomy in week 3. Control (Group 3) rats were given capsaicin only. Rats were given capsaicin showed no significant changes in body and liver weights. However, capsaicin with DEN caused significant enhancement of GST-P positive foci in numbers, areas and mean maximum diameter.
These results suggest that capsaicin has significant promoting potential in rat hepatic carcinogenesis.
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