5-Fluorouracil-Cisplatin(FP) 병용화학요법제의 Liposomes 이용의 실험연구 (II)
Experimental Cancer Chemotherapy of 5-Fluorouracil-Cisplatin (FP) Entrapped with Liposomes (II)
유용운, 이진오,
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유용운 ( )
한국에너지연구소 원자력병원 핵의학연구실
이진오 ( )
한국에너지연구소 원자력병원 핵의학연구실
KMID : 0360319880200010053
Abstract
The authors have investigated the effect of 5-Fluorouracil and Cisplatin entrapped with liposomes in experimental cancer chemotherapy.
As already known, Cisplatin alone may produce severe kidney damage, hearing loss, and bone marrow depression etc.
When Cisplatin or FP were entrapped with liposomes, the entrapped drugs offered better therapeutic effects in some aspects.
In tumor response test, the effects of FP entrapped with liposomes were dose-related on ICR mice bearing Sarcoma 180 cells.
In toxicity test, the liposomally entrapped drug reduced the severity of leukopenia and the elevation of serum uric acid significantly than the nonentrapped drug did.
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