원격전이 및 재발된 두경부 악성종양(편평상피암)에 대한 5-FU Infusion 및 Cisplatin (FP) 복합 화학요법
5-FU Infusion and Cisplatin in Patients with Disseminated or Recurrent Head and Neck Cancer
이재훈, 윤성수, 강윤구, 김승택, 방영주, 김노경, 김광현,
소속 상세정보
이재훈 ( )
서울대학교 의과대학 내과
윤성수 ( )
서울대학교 의과대학 내과
강윤구 ( )
서울대학교 의과대학 내과
김승택 ( )
서울대학교 의과대학 내과
방영주 ( )
서울대학교 의과대학 내과
김노경 ( )
서울대학교 의과대학 내과
김광현 ( )
서울대학교 의과대학 이비인후과
KMID : 0360319880200010067
Abstract
56 patients with dissminated or recurrent head and neck cancer were treated with 5-FU infusion and cisplatin between July, 1983 and June, 1986.
The results were as follows;
1) Among 54 evaluable patients, response rate was 48.1% (complete responses 7.4% partial responses 40.7%). Responserates of disseminated and recurrent group were 88.9% and 40%, respectively (p<0. 05).
2) Median time to disease progression was 4.4 months for overall patients, and 7.5 months and 2. 9 month for responders and nonresponders; there was statistically significant difference (P<0.05).
3) Median survival was 15.3 month for overall patients and 24.5 month and 9.2 month for responders and nonresponders; there was statistically significant difference (P<0.05).
4) Nausea and vomitting were observed in all patients but easily controlled, and stomatitis, alopecia, diarrhea were obrerved infrequently, leukopenia and thrombocytopenia were observed in 25.9% and 1.9%,
In conclusion, combination chemotherapy with 5FU infusion and cisplatin in patients with disseninated or recurrent head and neck cancer seemed to be relatively effective and well tolerable.
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