국한성 진행 두경부 악성종양(편평 상피암)에 대한 선행 화학요법 및 방사선요법의 병용치료 효과
Neoadjuvant Chemotherapy with 5-Fluorouracil Infusion and Cisplatin Followed by Radiotherapy for Locally Advanced Head and Neck Cancer
방영주, 윤성수, 박근철, 이재훈, 김승백, 김노경, 박찬일,
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방영주 ( )
서울대학교 의과대학 내과학교실
윤성수 ( )
서울대학교 의과대학 내과학교실
박근철 ( )
서울대학교 의과대학 내과학교실
이재훈 ( )
서울대학교 의과대학 내과학교실
김승백 ( )
서울대학교 의과대학 내과학교실
김노경 ( )
서울대학교 의과대학 내과학교실
박찬일 ( )
서울대학교 의과대학 치료방사선학과학교실
KMID : 0360319880200010082
Abstract
Thirty-two patients with previously untreated, locally advanced squamous cell carcinoma of the head and neck were treated with 2 or 3 cycles of combination chemotherapy consisting of 5-fluorouracil infusion and cisplatin (FP), followed by curative radiotherapy. Three patients(9%) achieved complete responses and 25(78%), partial responses after neoadjuvant chemotherapy. Following subsequent radiotherapy, 16(50%) achieved complete responses and 14(44%), partial responses, giving overall response rate of 94% with a median duration of response of 24.0+ and 9.5 months, respectively. The median survivals of the patients with complete and partial responses were 24.0+ and 11.0 months, respectively. The median survival of the patients with complete responses were significantly prolonged in comparison with that of those with partial responses. Toxicities from the treatments were common, but most of which were easily manageable and transient, with no treatment-related fatalities.
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