Hodgkin씨 병에 대한 Cyclophosphamide, Vincristine, Procarbazine, Prednisone(C-MOPP) 4제 복합화학요법의 치료효과
Combination Chemotherapy with Cyclophosphamide, Vincristine, Procarbazine, Prednisone (C-MOPP) in Hodgkin´s Disease
대한암학회지 1991년 23권 4호 p.806 ~ 813
정경해, 신동복, 김현아, 박영이, 김태유, 박근칠, 강윤구,
소속 상세정보
정경해 ( )
서울대학교 의과대학 내과학교실
신동복 ( )
서울대학교 의과대학 내과학교실
김현아 ( )
서울대학교 의과대학 내과학교실
박영이 ( )
서울대학교 의과대학 내과학교실
김태유 ( )
서울대학교 의과대학 내과학교실
박근칠 ( )
서울대학교 의과대학 내과학교실
강윤구 ( )
서울대학교 의과대학 내과학교실
KMID : 0360319910230040806
Abstract
Between November 1977 and December 1987, the combination chemotherapy with cyclophosphamide, vincristine, procarbazine, and prednisone (C-MOPP) had been administered in 29 patients with stage III-IV Hodgkin´s disease or recurrent cases after radiotherapy. Among 28 evaluable patients, 20 patients(71.4%) achieved complete responses and 8 patients(28.6%) had partial reaponses. The overall 5-year survival rate was 50.3% and the 5-year disease-free survival of complete responders was 55.7%. The frequent nonhematologic toxicties(WHO criteria gradezII) were alopecia(96.4%) and nausea/vomiting(42.8%) but hematologic toxicities were minimal. In conclusion, C-MOPP regimen was effective and well tolerated for the treatment of stage III-IV and recurrent Hodgkin´s disease.
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