더워지기의 항돌연변이물질 및 그 작용 기전
Animutagenic principle of Artemisia iwayomogi Kit and Its Action Mechanism
대한암학회지 1992년 24권 3호 p.352 ~ 358
소속 상세정보
배재민
김민선/박희준/정해영/양한석/박건영/문숙희/최재수
KMID : 0360319920240030352
Abstract
Artemisia iwayomogi(Compositae) is a herb drug which has been a choleretic drug in korea. Previously, we reported the antimutagenic activity of several kinds of crude drugs including Artemisia iwayomogi in the Ames mutagenicity test. In the
present
paper, the antimutagenic effect of methanol extract, its fraction and component against aflatoxin(AFB1) in the salmonella assay system was studied. The methanol extract of Artemisia iwayomogi markedly inhibited the mutagenicity induced by 76%,
79%
and
78%, respectively, The active component, scopoletin, was isolated from the chloroform fractions which has the antimutagenic effect. The scopoletin also inhibited the lipid peroxidation in vitro and vivo and showed an antioxidant effect.
Therefore,
the
antioxidant activity can be considered for a mechanism of antimutagenic action of scopoletin.
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