악성 흉막액과 복수내 Ferritin의 진단적 가치
Diagnostic Value of Ferritin in Malignant Pleural and Peritoneal Effusions
대한암학회지 1992년 24권 4호 p.531 ~ 540
소속 상세정보
정태준
변정원/장정순/최일영/고응린/최보율
KMID : 0360319920240040531
Abstract
The diagnostic usefulness of ferritin measurements in pleural and peritoneal effusion has been evaluated in 55 patients. patients were divided into 4 groups according to the location and the character of effusions.
Ferritin concentrations in serum and effusions were invariably higher in cancer patients than in nonmalignant conditions. Effusion fluid ferritin level and effusion/serum ferritin ratio was statistically higher in pleural effusion patients than
in
peritoneal effusion bearing hosts.
In patients with pleural effusion, effusional ferritin concentration has the best diagnostic value. At cut-off point of 891 ng/dl, diagnostic specificity was 75% but sensitivity was 100%. Although seum ferritin level can also be used for the
diagnosis
of malignant pleural effusions when its concentration exceeds 125.9ng/dl, the specificity is only 40% while the sensitivity is 100%.
In patients with peritoneal effusion, effusion/serum ferritin ratio could provide better differentiation for malignant conditions. At cut-off point of 0.63 its diagnostic specificity was 84.6% and sensitivity 100%.
There results indicate that the measurement of ferritin levels and ferritin ratios may be a useful aid in the diagnosis of malignant pleural and peritoneal effusions.
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