TAP로 야기된 HL-60 세포의 기질부착 저해작용을 이용한 Protein Kinase C 저해 생약의 탐색
Screening of Protein Kinase C-inhibiting herbs using TPA-induced Adherence of HL-60 Cell
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김선희
안종석/김삼용/유관희/안병준
KMID : 0360319930250010009
Abstract
Thirty-five kinds of herbal drugs, believed to be active for treatment of tumors, were selected as the experimental materials for observing their effects on TPA-induced adherence of HL-60 cell and activity of protein kinase C. They were extracted
with
ethyl ether(E) and ethyl acetate(EA), methanol(M) in sequence. Among the extracts, Sophorae Flos(EA), Paeoniae Radix (EA), Equisetum hiemale(EA), phellodendri cortex(E, EA), Mori Cortex radicis(EA), Ferula assafoetida(E, EA), Sophora
subprostrata(EA, M)
and Cnidium monnieri(E) inhibited the TPA-induced adherence ofHL-60 cell more than 50% and Sophorae Flos(E, EA, M), Paeoniae Radix(E, EA, M), Equisetum hiemale(E), Phellodenri Cortex(E, M), Mori Cortex radicis(M), Ferula assafoetida(M), Sophora
subprostrata(EA, M), Cnidium monnieri(M) and Artemisia argyi(M) showed inhibiting effects on the activity of protein kinase C more than 50%.
The extracts showing good inhibiting effects on the adherence and enzyme activity were Sophorae Flos(EA), Paeoniae Radix(EA), Phellodendri Cortex(E), Sophora subsprostrata(EA) and Equisetum hiemale(EA).
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