벤조피렌, 디메칠니트로사민 및 디부틸니트로사민에 의한 마우스 다장기 발암모델 확립에 관한 연구
Lack of Multi-Organ Carcinogenesis in Female N: GP(S) Mice by Benzo(a)pyrene, Dimethylnitrosamine and Dibutylnitrosamine
대한암학회지 1993년 25권 4호 p.572 ~ 577
이윤실, 장자준, 조경자,
소속 상세정보
이윤실 ( )
원자력병원
장자준 ( )
원자력병원
조경자 ( )
원자력병원
KMID : 0360319930250040572
Abstract
A wide-spectrum initiation model was investigated in female N: GP(S) mice. Sequential treatments with benzo(a)pyrene (BP), dimethylnitrosamine(DMN), with or without N-methylnitrosoures(MNU), resulted in tumor formation in the lungs in 84.2%~90.0%
of
animals, but did not produce any tumorous lesions in other organs. The lung tumors were mainly adenomas and 4 cases showed carcinoma in adenoma. The mean number of adenoma was 13.2~16.2 per mouse. MNU combination had no additive effect on the
lung
tumor
incidence, but significantly increased the lung tumor multiplicity. The carcinogen-treated animals showed cytomegaly of hepatocytes and this was more marked in MNU combined group. These results showed that a wide-spectrum initiation model was not
established in this mouse system. Further study with a change in mouse strain or in combination of carcinogen, or increment of carcinogen dose would be necessary.
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