유암조직에서 카뎁신-D의 발현과 임상병리학적 예후인자들과의 상관관계
Immunohistochemical Assay of Cathepsin-D in Breast Carcinomas: Comparison with Age Tumor Size, Lymphnode Invasiveness and Estrogen Receptor
대한암학회지 1993년 25권 5호 p.658 ~ 663
소속 상세정보
한세환
노동영/최국진/김진복/이왕재/박인애
KMID : 0360319930250050658
Abstract
Cathepsin-D is considered to be an independent prognostic factor in breast cancer patients from many other studies. We have performed immunohistochemical assay with polyclonal antibody specific to the cathepsin-D in paraffin blocks of one hundred
and
one breast cancer specimens. All the patients were female and positive ratio of cathepsin-D was 58.4%(59 cases). These results were compared with ER status, tumor size, lymphnode invasion and with the age of the patients. In the patients with age
less
than fifty years old, thirty four cases(52.3%) were cathepsin-D positive, and twenty five cases(69.4%) were cathepsin-D positive in older than fifty years of age. In the relationship with size of tumors, ten cases(50.0%) were positive in the
tumors
smaller than 2 cm, thirty six cases(62.1%) were positive in the tumors with the size between 2 cm and 5 cm and thirteen cases(56.5%) were positive with the tumors larger than 5 cm. With respect to the axillary lymphnode involvement, twenty five
cases(55.6%) were positive in the negative group and twelve cases(57.1%) were positive with the group less than four lymphnodes involvement and twenty two cases(62.9%) were positive in the group four or more lymphnodes involvement. In the ER
negative
group nineteen cases(55.9%) were positive and thirty one cases(58.5%) were positive in ER positive group.
In the results of our study, there were little relationships between cathepsin-D and other classical prognostic factors including estrogen receptor in breast carcinoma patients.
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