Retinoic acid가 백서의 피하에 주입된 신경아세포종(neuroblastoma)의 성장 및 백서의 생존에 미치는 영향
Effect of Retinoic Acid on the Growth of Subcutaneously Injected C1300 Neuroblastoma and on the Survival of the Host A/J Mice
대한암학회지 1994년 26권 1호 p.113 ~ 118
박희붕, 조병준, 장미숙,
소속 상세정보
박희붕 ( )
연세대학교
조병준 ( )
연세대학교
장미숙 ( )
연세대학교
KMID : 0360319940260010113
Abstract
Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds(retinoids) have demonstrated activities in several cancerous and
precancerous
conditions. We measured the effects of a retinoic acid on the growth of subcutaneously injected C1300 neuroblastoma and on the survival of the host A/J mice. The fifty A/J mice were inoculated with 106 of C1300 neuroblastoma cell in the right
back.
They
were divided into five groups. One group received saline as a control. Two groups recieved 2mg/kg and 5mg/kg of retinoic acid . The other two groups recieved low dose(50mg/kg and 100mg/kg) cysclophosphamide. Tumor volume and survival were
assessed.
The
survivals were significantly increased(p<0.05) in three groups, mice recieved 5mg/kg of retinoic acid, 50mg/kg and 100mg/kg of cyclophosphamide. Tumor volumes of the mice treated with 5mg/kg of retinoic acid were significantly lower than the
control
group(p<0.05). Retinoic acid suppressed the growth of neuroblastoma, it increased the survival of the treated mice if adequate doses were used.
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