소아 급성골수성백혈병 환자의 화학요법에 따른 호중구 감소에 대한 Filgrastim(rhG-CSF)의 효과
Effect of Filgrastim(rhG-CSF) on Chemotherapy Induced Neutropenia in Pediatric Acute Myelogenous Leukemia Patients
대한암학회지 1994년 26권 1호 p.136 ~ 143
신희영, 박경덕, 하성훈, 구홍회, 안효섭,
소속 상세정보
신희영 ( Shin Hee-Young )
서울대학교 의과대학 소아과학교실
박경덕 ( Park Kyung-Duk )
서울대학교 의과대학 소아과학교실
하성훈 ( Ha Seong-Hoon )
서울대학교 의과대학 소아과학교실
구홍회 ( Koo Hong-Hoe )
울산대학교 의과대학 소아과학교실
안효섭 ( Ahn Hyo-Seop )
서울대학교 의과대학 소아과학교실
KMID : 0360319940260010136
Abstract
To determine the safety and efficacy of rhG-CSF on chemotherapy induced neutropenia in pediatric AML patients, we conducted a prospective controlled study in 17 patiens with AML at Seoul National University Childrens Hospital from July, 1993 to January, 1994. High dose cytosine arabinoside(Ara-C, 3gm/m for four times every 12 hours) with L-asparaginase 6,000 u/m) were given to 13 patients as Group I control and after the recovery of WBC, same chemo- therapy followed by G-CSF(50 ug/m for 10 days) were given as Group I study. In Group II study, high dose Ara-C(3gm/m(2) for 8 times every 12 hours) were given to 11 patients with AML followed by G-CSF(150 ug/m for 10 days). Recovery of the absolute neutrophil counts to more than 1,000/mm’ was significantly faster in the G-CSF group than in the control group(P< 0.01) and the absolute neutrophil counts on day 14 of chemotherapy was significantly higher in G-CSF group(P<0.01). The toxicity of G-CSF was minimal and there was no evidence of accel- erated growth of leukemic blasts during the G-CSF treatment. In conclusion, Filgrastim(rhG- CSF) promotes the recovery of neutrophils and shortens the duration of neutropenia induced by the chemotherapy in pediatric acute myelogenous leukemia.
Key words: Filgrastim, G-CSF
키워드
Filgrastim; G-CSF; Childhood; AML; Neutropenia; Chemotherapy
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