고형암의 항암제 치료후 발생하는 호중구감소증에 대한 Granulocyte Colony Stimulating Factor(G-CSF)의 효과
The Effects of Granulocyte Colony Stimulating Factor on Neutropenia Induced by the Chemotherapy in the Solid Tumor Patient
대한암학회지 1994년 26권 1호 p.144 ~ 150
소속 상세정보
신상원
남용진/최철원/송관규/김준석/김순덕/김영홍
KMID : 0360319940260010144
Abstract
We evaluated the effect of granulocyte colony stimulating factor (G-CSF) to prevent chemotherapy induced neutropenia and fever development during neutropenic period. The twenty patients with solid tumor were treated with various cytotoxic
chemotherapeutic agents at least two cycles. The patients were given G-CSF 75μg/day after 2nd cycle chemotherapy for least 14 consecutive days and clinical, laboratory results were compared to the first cycle's results.
Treatment with G-CSF resulted in increase of mean neutrophil count(320±230/㎣ vs 1030±1020/㎟), reduced the duration of neutropenic days(4.25 days vs 1.30 days, absolute neutrophil count less than 500/㎣) and reduced the incidence of
neutropenic
fever(75% vs 25%).
The side effect of G-CSF was not so significant.
These results demonsrated that the use of G-CSF as an adjunct to chemotherapy with various solid cancer patients was well tolerated and led to reduction in the incidence of neutropenic fever; in the terms of incidence, duration, and severity of
neutropenia.
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