위암종에서 p53 단백 과발현과 환자의 예후와의 관계에 대한 연구
Prognostic Significance of p53 Overexpression in Gastric Carcinoma
대한암학회지 1994년 26권 5호 p.702 ~ 710
소속 상세정보
김우호
송상용/김종재/김용일/김진복
KMID : 0360319940260050702
Abstract
The overexpession of p53 protein was immunohistochemically studied in a total of 92 gastric carcinomas, of which 40 cases(43.5%) showed nuclear immunoreactivity. Older age(p<0.001), lymph node metastasis(p<0.05), stage(p<0.05), and higher
expression of
proliferating cell nuclear antigen(p<0.05) were correlated with p53 overexpression. Other clinicopathologic parameters including sex, tumor site, WHO classification, Ming classification, inflammation degree, desmoplasia degree, tumor invasion
depth,
gross type, size, and recurrence were not related with p53 overexpression. However, intestinal type(56.3%) by Lauren classification and advanced gastric carcinoma(48.0%) showed higher incidence of p53 overexpression than diffuse type(36.7%) and
early
gastric carcinoma(23.5%), respectively(0.05with
patients survival. We concluded that p53 overexpression was common event in gastric carcinogenesis and may play role not in late, invasive stage of tumor progression related with patient survival, but in early, proliferative stage of gastric
carcioma
progression.
키워드
원문 및 링크아웃 정보
등재저널 정보