위암에서 Estrogen 수용체에 대한 연구
A Study of Estrogen Receptors in Gastric Cancer
대한암학회지 1994년 26권 5호 p.722 ~ 727
배문오, 홍순관, 김영진,
소속 상세정보
배문오 ( )
전남대학교
홍순관 ( )
전남대학교
김영진 ( )
전남대학교
KMID : 0360319940260050722
Abstract
Recently the presence of estrogen receptor(ER) has been demonstrated in some cases of cancer of the digestive tract such as stomach, large intestine, pancreas and the liver which are non-target organs of sex hormones.
The authors studied ER in tumors from 95 gastric adenocarcinomas using immunohistochemical staining with monoclonal antibody. DNA ploidy using flow cytometry was also assessed in 75 cases of gastric carcinomas.
ER positivity was 40 of 95(42.1%) gastric carcinomas. The tendency of receptor positivity increased with progression of tumor and lower differentiation. There was no positive relationship between ER positivity and sex, age, gross type, DNA ploidy
and
the level of carcinoembryonic antigen.
The results of this study show that hormonal factors are involved in gastric carcinomas and that the cancers have endocrinic characteristics. The studies clarifying the role of hormones to cancer cells will be valuable in the design of hormonal
therapy.
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