화성분석기를 이용한 유방암의 AgNORs의 수와 면적 측정
Quantitation of AgNORs in Breast Lesions Using Image Analysis
대한암학회지 1994년 26권 5호 p.756 ~ 763
김애리, 김영식, 김인선,
소속 상세정보
김애리 ( )
고려대학교 의과대학 부속병원
김영식 ( )
고려대학교 의과대학 부속병원
김인선 ( )
고려대학교 의과대학 부속병원
KMID : 0360319940260050756
Abstract
The argyrophilic nucleolar organizer regions(AgNORs)staining is one of the useful methods for the estimation of proliferative activity in conventional histologic sections in various benign and malignant lesions. Because of difficulties in AgNORs
counting, there is a relucance to accept the technique as a reliable diagnostic tool.
We measured the area and numbers of AgNORs in 22 surgically resected infiltrating ductal carcinomas and 5 fibroadenomas using image analyzer and also visually enumerated the numbers at (1000magnification. The number of AgNORs by visual conuting
was
correlated with the area measured by Image counting(r-0.56). The mean area of AgNORs in the malignant group(4.36μ㎡) was significantly different(p<0.0001) from that of the benign group(0.79μ㎡). As the number of AgNORs increased, the area
increased(r=0.709).
The result of this study suggests that measurement using image analyzer can give more objective and reproduccible measurement of AgNORs than visual counting.
키워드
원문 및 링크아웃 정보
등재저널 정보