유방암에서의 p53 발현 -원발병소와 전이병소의 비교-
p53 Expression in Breast Cancer -Comparison between primary and metastatic lesions-
대한암학회지 1994년 26권 5호 p.764 ~ 769
소속 상세정보
황태숙
김영배/주영채/김준미/조경자/장자준
KMID : 0360319940260050764
Abstract
Accumulation of mutated p53 protein in paired primary breast cancers and their metastatic axillary lymph node lesions are evaluated by immunohistochemical method to compare the difference between primary and metastatic foci.
Among 75 cases, 19 cases showed increased p53 expression and 1 case showed decreased expression in metastatic foci compared to the primary foci.
This nuclear protein was expressed only in the nuclei of the neoplastic cells except for one case which showed positive reaction in the nuclei of the hyperplastic ductal epithelium. This oncoprotein was expressed heterogenously in both primary
and
metastatic foci and appeared to be distributed more prominently in the invasive margins.
We concluded : 1) mutated p53 protein expression is heterogenously distributed 2) this mutated p53 protein expression was more frequent and increased in metastatic foci than primary foci 3) p53 gene mutation may be involved in breast cancer
progression
and evolution of metastatic subclone.
키워드
원문 및 링크아웃 정보
등재저널 정보