Hodgkin씨 병 환자에서 과량의 Vinblastine 투여후 발생한 독성
Serious Toxicities Induced by Vinblastine Overdose in a Patient with Relapsed Hodgkin's Disease
대한암학회지 1994년 26권 5호 p.841 ~ 846
소속 상세정보
한상국
김용주/한지연/강진형/문한림/홍영선/김훈교/이경식/김동집
KMID : 0360319940260050841
Abstract
Vinblastine, refereed to as a vinka alkaloid, has been used as a component of the various chemotherapeutic regimens in the treatment of nonseminomatous testicular carcinoma, choriocarcinoma, non-small cell lung carcinoma, bladder cancer, head and
neck
cancer and cervical cancer. Vinblastine has been used as a main component of ABVD combination therapy for the patients with advanced advanced Hodgkin's disease who relapsed after therapy with the MOPP regimen.
The major adverse effects of usual dosage of vinblatine are myelosuppression, nausea, vomiting, local effects(phlebitis, necrosis when extravasated), and peripheral and autonomic neuropathies.
We experienced the life threatening toxicities including bone marrow suppression, oral mucositis, peripheral neuropathies and paralytic ileus in a 41-year-old male patients with relapsed Hodgkin's disease who was errorneously treated with 50 mg
of
vinblastine. The patient was recovered completely with intensive supportive treatment.
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