한국인 유방암 환자에서 c-erbB-2 Oncoprotein 및 Epidermal Growth Factor Receptor(EGFR) 발현에 관한 연구
The Expression of c-erbB-2 Oncoprotein and Epidermal Growth Factor Receptro(EGFR) in Breast Cnacer Patients in Korea
대한암학회지 1994년 26권 6호 p.901 ~ 911
소속 상세정보
박원
백남선/김용규/문난모/이종인/최동욱/황대용/장자준
KMID : 0360319940260060901
Abstract
Samples of breast carcinoma were collected from 117 patients who underwent mastectomy in Korea Cancer Center Hospital from Jan. 1982 to Dec. 1984. We studied expression of the c-erbB-2 oncoprotein and EGFR with the immunohistochemical technique.
We
also
analyzed to clarify the relationship between expression of the c-erbB-2 oncoprotein and/or EGFR and tumor size, node metastasis, stage, histologic grade, TIL, and EIC, and to evaluate the prognostic significance of c-erbB-2 oncoprotein and EGFR
in
breast cancer. EGFR expression rate was 37.6%(44/117) and EGFR status had positive correlation with histologic grade(p<0.05). But, we did not find any other relationship with other clinicopathological prognostic factors. C-erbB-2 expression rate
was
64.1%(71-117). There was no relevance between c-erbB-2 expression and other prognostic factors. Higher histologic grade was poorer survival rate. EGFR positive patients had poorer prognosis than negative patients in stage I and Ⅱbreast
cancer(p<0.05).
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