유방암 예후 인자로서 DNA Ploidy 의의
Prognostic Significancy of the DNA Ploidy in Breast Cancer
대한암학회지 1994년 26권 6호 p.943 ~ 949
장혜정, 동진근,
소속 상세정보
장혜정 ( )
경북대학교 의과대학 안과학교실
동진근 ( )
경희대학교
KMID : 0360319940260060943
Abstract
Flow cytometric DNA ploidy measurements using paraffin embeded tumor specimen were performed in 60 breast cancer patients. Twenty-six patients (43.3%) of the cases were diploid, thirty-four(56.7%) were aneuploid, DNA idex(DI) of histogram showed
bimodal
distribution and DI value of second peak incidence was 1. 7. The DNA ploidy was not correlated with tumor size, lymph node involvement, progesterone receptor status, histologic type and menopausal status, but significantly correlated with
estrogen
receptor status. Postoperative clinical survey demonstrated a high tendency of recurrence rate and shorter survival time of patients with aneuploid tumors as compared those with diploid tumors.
These results suggested that DNA ploidy is considered to be useful prognostic factor in human breast cancer.
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