소아기 악성고형종 환자의 항암화학요법후 호중구감소증에 대한 Recombinant Human GM-CSF의 효과
Effect of rhGM-CSF on the Chemotherapy-induced Neutropenia of Children with Solid Tumors
대한암학회지 1995년 27권 2호 p.322 ~ 330
서종진, 차상원, 이상미, 김규돈,
소속 상세정보
서종진 ( )
충남대학교
차상원 ( )
충남대학교
이상미 ( )
충남대학교
김규돈 ( )
충남대학교
KMID : 0360319950270020322
Abstract
To investigate the clinical effectiveness of recombinant human GM-CSF(rhGM-CSF;Leucogen ) on the chemotherapy-induced neutropenia, twelve children with malignant solid tumor who had neutropenia after chemotherapy received 250μg/M*/day of
rhGM-CSF
subcutaneouly for 10 consecutive days from the fifth day of next chemotherapy were schedule using the same regimen.
rhGM-CSF significantly increased leukocyte, neutrophil and eosinophil counts on the tenth day of GM-CSF course compared to the control course(p<0.05), but there was no significant difference in the counts of monocyte, lymphocyte, platelet or
hemoglobin(P>0.1). The nadir of leukocyte and neutrophil were significantly higher in GM-CSF course than hose of control course (p<0.05), but there was no significant difference in that of monocyte, lymphocyte, eosinophil, platelet or
hemoglobin(P>0.1).
The duration of chemotherapy-induced leukopenia and neutropenia were decreased significantly in GM-CSF course than those of control course(p<0.05). The duration of antibiotics administration and febrile period during chemotherapy were shorter in
GM-CSF
course without statistical significance. No significant side effect was observed during rhGM-CSF course.
Thses results indicate that rhGM-CSF(Leucogen ) is effective in alleviating the chemotherapy-induced neutropenia of children with malignant solid tumors.
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