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Multicentric Castlemanº´ 1¿¹ A Case of Multicentric Castleman's Disease

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Abstract


Multicentric Castleman's disease is a systemic lymphoproliferative disorder. characterized by generalized lymphadenopathe, multisystem involvement, disordered immunity and an increased incidence of malignant tumors, particularly Kaposi's sarcoma
and
lymphoid neoplasia.
The clinical presentation and laboratory features of this syndrome are similar to those of another atypical lymphorliferative disorder, angioimmunoblastic lymphadenopathy with dysproteinemia, although this is histologically different from
Castleman's
disease.
A 21-year old male presented to us with complaints of arthralgia and myalgia of 4 months duration, followed by 2 weeks of high fever.
Initial physical findings showed small, generalized lymphadenopathies in cervical, axillary and inguinal areas.
He developed hepatosplenomegaly and pleuropericardial effusions rapidly.
Lymph node biopsy from left inguinal area was consistent with angiofollicular lymph node hyperplasia, plasma cell type.

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